Guidelines for nucleic acid detection and analysis in hematological disorders.

Nucleic acid detection in hematological disorders has been carried out in a wide range of medical fields or departments. Hence, it is recommended that the hematology laboratory should draw up guidelines or a manual for each disease (group), field or specialty. Nucleic acid detection is defined as processes which are disclosed using depolymerization of a nucleic acid hybrid (deoxyribonucleic acid; DNA or Ribonucleic acid; RNA) to qualitatively or quantitatively analyze for the presence of a predetermined nucleic acid. Applications of these processes include the detection of single nucleotide polymorphisms, identification of single base changes, genotyping and medical marker for diagnostics purposes.